Banca de DEFESA: KARLA FLAVIANA CARNEIRO CASTELO BRANCO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: KARLA FLAVIANA CARNEIRO CASTELO BRANCO
DATA: 19/09/2013
HORA: 18:00
LOCAL: Auditório da Faculdade de Odontologia
TÍTULO: "Avaliação da via de sinalização do AKt e proteínas relacionadas, no comportamento biológico do adenoma pleomórfico e carcinoma adenoide cístico"
PALAVRAS-CHAVES: signaling pathway; salivary gland; pleomorphic adenoma; adenoid cystic carcinoma Abbreviations: PA, pleomorphic adenoma; ACC, adenoid cystic carcinoma; SG, salivary gland
PÁGINAS: 48
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Clínica Odontológica
RESUMO: Objective: To determine the immunoexpression of Akt, β-catenin, Cyclin D1, COX-2, NFκB and p-Akt in pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) and to establish a possible correlation among these proteins within the cellular signaling pathway. Study Design: The expression of the proteins was assessed by immunohistochemistry in 20 PA, 10 ACC and 7 normal salivary gland (SG) cases. Results: The Kruskal-Wallis test revealed a significant difference in the β-catenin, COX-2,NFκB and pAkt expression between the ACC and SG groups and the β-catenin, COX-2 and NFκB expression between the PA and SG groups. In addition, a significant positive correlation was found between the expression of Akt/β-catenin, Akt/NFκB, Akt/p-Akt, p-Akt/NFκB, p- Akt/β-catenin, p-Akt/Cyclin D1, p-Akt/COX-2, β-catenin/COX-2, β-catenin/NFκB, NFκB/Cyclin D1 and Cyclin D1/COX-2 in ACCs, according to Spearman’s correlation test. Conclusions: The p-Akt/NFκB/β-catenin/COX-2 signaling pathway can be activated in ACCs,and the NFκB and β-catenin/COX-2 can be activated in PAs.
MEMBROS DA BANCA:
Interno - 1152832 - JOAO DE JESUS VIANA PINHEIRO
Externo ao Programa - 326568 - MARIA SUELI DA SILVA KATAOKA
Presidente - 1640241 - SERGIO DE MELO ALVES JUNIOR