Notícias

Banca de DEFESA: DIELLE SILVA DE ALMEIDA MARTINS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: DIELLE SILVA DE ALMEIDA MARTINS
DATA: 10/07/2014
HORA: 15:00
LOCAL: HHJBB - Prédio da Anatomia Patológica
TÍTULO: Overexpression of NF-κB in oral squamous cell carcinoma is associated with smoking and with degree of differentiation.
PALAVRAS-CHAVES: Oral squamous cell carcinoma, immunohistochemistry, biological markers, survival
PÁGINAS: 17
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Clínica Odontológica
RESUMO: Abstract Oral squamous cell carcinoma (OSCC) is the primary malignant lesion of the mouth, accounting for over 95% of cases. Despite advances in surgical techniques as well as radiotherapy and chemotherapy, the prognosis of the disease has not improved, with low survival rates. The most used method in the prognostic evaluation of squamous cell carcinoma takes into account the TNM system, where (T) is the lesion size, (N) is the infiltration of metastatic lymph nodes, and (M) is distant metastases, an analysis defined in 2002 by the Union International for the Control of Cancer. However, this method of evaluation has a limited predictive value. It is urgent understanding of molecular biomarkers to clarify the clinical behaviour of this tumour in order to individualise therapy in these patients. The aim of this study was to analyse immunohistochemical staining of the protein NF-κB in OSCC tissue samples and evaluate the potential correlation between expression status and clinicopathological features, as well as with the patient’s survival or mortality. Our results showed no association between immunostaining of NF-κB protein and overall survival of patients, data measured by the Log Rank Test (p = 0.727). The chi-squared value proved to be significant in the histological grade (p = 0.036) and in smokers (p = 0.037). These results confirm the involvement of NF-κB in oral carcinogenesis associated tobacco smoke. Additionally, a significant increase in NF-κB levels correlated with tumour dedifferentiation in OSCC, suggesting its association with disease progression.
MEMBROS DA BANCA:
Presidente - 3301328 - FLAVIA SIROTHEAU CORREA PONTES
Interno - 1258980 - HELDER ANTONIO REBELO PONTES
Externo ao Programa - 2008262 - NICOLAU CONTE NETO
Notícia cadastrada em: 27/09/2013 11:55
SIGAA | Centro de Tecnologia da Informação e Comunicação (CTIC) - (91)3201-7793 | Copyright © 2006-2024 - UFPA - castanha.ufpa.br.castanha2