Banca de DEFESA: VERENA KARLA MONTEIRO LOPES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: VERENA KARLA MONTEIRO LOPES
DATA: 23/03/2016
HORA: 14:30
LOCAL: PPGO-UFPA
TÍTULO:

''Immunohistochemical expression for Ki-67, P27 And MCM3 in Oral Squamous Cell Carcinomas associated with clinicopathological and prognostic outcomes''

PALAVRAS-CHAVES:

 Squamous Cell Carcinoma, Biomarkers, Survival.

PÁGINAS: 27
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Radiologia Odontológica
RESUMO:

Proliferative activity and differentiation of tumor’s cells is an essential parameter that determine the course and the prognosis of the disease. The aim of this study was to investigate the immunoexpression patterns for Ki-67, MCM3 and p27 in oral squamous cell carcinoma (OSCC) as well as to address the correlation with patient’s survival and clinicopathological features. Fifty-one patients were enrolled. The clinical (tumor size, tumor staging, lymph nodal involvement and survival) and pathological characteristics (differentiation grade) of the patients were recorded. The expression of Ki-67, MCM3 and p27 was evaluated with immunohistochemical methods using paraffin blocks. The mean-age of patients was 63.89 year. The association was examined for statistical significance using chi-square test. Overall survival rates were estimated by the KaplanMeier method and compared using a log rank test (P > 0.05). The results indicated a statistically immunostaining significance for the expression of Ki-67 and survival rate (p = 0,00882). From these results, the present study suggest that high Ki-67 expression found in OSCC patients may contribute to tumor growth and survival rate.

MEMBROS DA BANCA:
Externo ao Programa - 1258980 - HELDER ANTONIO REBELO PONTES
Externo ao Programa - 326379 - KUNIHIRO SAITO
Presidente - 1697865 - PEDRO LUIZ DE CARVALHO